Nuvora, Inc. the maker of innovative oral care lozenges demonstrates in a clinical pilot study that a fluoride lozenge significantly raises fluoride levels in saliva for up to one hour after use

Santa Clara, CA (July 30, 2010)

Nuvora, Inc. the developer and manufacturer of Salese dry mouth products announced today results of a clinical pilot study in which it demonstrated that a Nuvora fluoride lozenge can raise fluoride level in saliva for up to one hour after product usage when compared to a placebo lozenge.  The clinical study was conducted by B.M.T Rechmann and M.L. Rapozo-Hilo at the University of California, San Francisco and presented at the International Association of Dental Research (IADR) General Session, Barcelona, Spain, July 2010.

This double blind, three-leg cross-over pilot study enrolled 12 caries free, normal healthy subjects aged 20 to 42 years of age.  Study participants were directed to use 3 lozenges per day for 1 hour after breakfast, lunch and dinner.  3 lozenge formulations were tested: 0.5mg F as NaF, 1.5 mg F as NaF and 0mg F as a negative control.

Both fluoride containing lozenges (0.5mg F, 1.5mg F) resulted in significantly higher saliva fluoride levels than the placebo control lozenge (0mg F) at every sampling time (p<0.05).

Mean Fluoride Levels (ppm F, mean +/- SD)

 “The study results demonstrate that the underlying technology of our lozenges has significant potential to improve oral health”, said Jerry Gin, CEO of Nuvora, Inc. “While further studies are needed the opportunity to deliver fluoride in the oral cavity for an extended period of time should have a huge impact in the effort to reduce cavities world wide”.

Long-term, low-level salivary fluoride concentration is extremely effective in caries prevention and enhances the rate of enamel re-mineralization.  However, readily available fluoride products such as OTC toothpaste or mouth rinse remain in the oral cavity for a short period of time only before they are expelled.  Any remaining fluoride is quickly washed away by saliva.

About Nuvora, Inc.

Nuvora, Inc. is a Santa Clara, California company focused on developing innovative oral care products.  The company was started by experienced drug delivery experts with a proven track record in taking a variety of ground breaking delivery technologies from concept through clinical trials to market.  Nuvora has licensed a proprietary Sustained Release technology (SuRe™) from Bennes, Inc. that may be used to form a long-lasting ‘lozenge’.  This lozenge which can last anywhere from 30 minutes to over 2 hours, acts upon the oral cavity with substantially lower therapeutic doses of active ingredients for a substantially longer duration.  As a result, the SuRe technology may achieve unprecedented prolonged activity and efficacy for ingredients delivered in the oral cavity.  Nuvora, Inc. currently manufactures and markets Salese™ for Dry Mouth (Xerostomia), NuvoraBreath™ for Halitosis and Dentiva™ for general oral hygiene.

Contact:
Patrick Wilson
1.877.530.9811
pwilson@nuvorainc.com

www.nuvorainc.com